Dose Response for SSRIs

Treatment for Depression After Unsatisfactory Response to SSRIs Executive Summary

Depression is a complex mental illness associated with disability and reduced quality of life for the person with depression, as well as substantial societal burden. Major depressive disorder (MDD) is the second leading medical cause of long-term disability, the fourth leading cause of global burden of disease, and is predicted to become the second highest cause of disability by 2020.1,2 Depres...

GIRK Channels as a Target for SSRIs

Familial Trichotillomania Responding to SSRIs

Trichotillomania is term used to denote an irresistible urge to pull one’s own hair. It is classified under ‘Habit and Impulse Disorders’. There are few reports of familial occurrence of trichotillomania but none on response to the same SSRI among family members afflicted with trichotillomania. We present a young girl with trichotillomania, who had a family history in her mother. Both responded...

Dose-response relationship for breast cancer induction at radiotherapy dose

PURPOSE Cancer induction after radiation therapy is known as a severe side effect. It is therefore of interest to predict the probability of second cancer appearance for the patient to be treated including breast cancer. MATERIALS AND METHODS In this work a dose-response relationship for breast cancer is derived based on(i) the analysis of breast cancer induction after Hodgkin's disease,(ii) ...

Choosing between SSRIs and TCAs.

I n the article " Pharmacologic treatment of depression in late life " Alastair Flint gives a thorough and comprehensive review of the treatment of depression. He mentions that to his knowledge, " only 1 trial has compared an SSRI [selective serotonin reuptake inhibitor] (sertra-line) with a secondary amine TCA [tricyclic antidepressant] (nortripty-line), and both drugs were equally well tolera...